Cilento study
    Web site for the cohort:
http://www.igb.cnr.it/cilentoisolates/
    Publications describing the cohort:
  1. Siervo M, Ruggiero D, Sorice R, Nutile T, Aversano M, Stephan BC, Ciullo M. Angiogenesis and biomarkers of cardiovascular risk in adults with metabolic syndrome. J Intern Med. 2010 Oct; 268(4): 338-47.
  2. Colonna, T. Nutile, M. Astore, O. Guardiola, G. Antoniol, M. Ciullo* and M.G. Persico. Campora: a young genetic isolate in South Italy. Hum Hered. 2007; 64,123-35
  3. Colonna, T. Nutile, R.R. Ferrucci, G. Fardella, M. Aversano, G. Barbujani, M. Ciullo. Comparing population structure as inferred from genealogical versus genetic information Eur. J. Hum.Genetics 2009; 17, 1635-41
    Description
: Cilento study is a population-based study that aims at identifying genetic risk factors for common diseases and traits. The sample includes isolated populations from three villages (Campora, Gioi and Cardile). These villages underwent a bottleneck due to the plague of the XVII century that reduced to a very few people these populations. We have demonstrated using genealogies and genetic data that these villages have all features of genetic isolates (Colonna et al. 2007; Colonna et al 2009). The overall sample size of individuals participating to the study is 2100. All inhabitants of the selected isolated populations are invited to participate to the study. The decision to participate is voluntary and it is first linked to the desire of the single person to participate to the study and then to the former approval of a parent (or a delegate) if this is needed. In both cases we explain clearly, with dedicated staff, using a clear and comprehensible language (a language that is related to cultural level and age of the individual) the objectives of the study. We do not accept participants that are not able to understand what is written into our “informed consent” form.
    Types of tissue collected
: Blood, plasma, serum