The LifeLines Cohort Study and BIobank (LLs)
    Web site for the cohort:
    Publication describing the cohort:
  1. Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BH.. Universal risk factors for multifactorial diseases LifeLines: a three-generation population-based study. Eur J Epidemiol. 2008;23(1):67-74.
Population-Based Healthy Subjects. LifeLines offer a national infrastructural resource, which contributes samples to a increasing number of various research projects. The LifeLines cohort study and Biobank, aims to determine common risk factors in multifactorial diseases. It includes detailed measurements of environmental factors, endophenotypes and genotypes of participants. LifeLines is a large observational study which consists of a three-generation cohort in the northern part of the Netherlands. Furthermore, it contains genetic data on the whole-genome that helps to analyse more advantageously the links between genetic predispositions and common complex diseases. Since Dec 2006, over 167,729 participants 0-93 years old have been included to the LifeLines cohort study. Out of 15,000 participants, whose genome wide genotyping has been performed, 4000 subjects will be included to this study. The outcomes and determinants of LifeLines are measured on face-to-face interview between participant and LifeLines trained assistant or physician. Participants are asked to fill a number of extended questionnaires, which include medical history with information about baseline factors, socioeconomic status, psychological status, environmental factors food frequency questionnaires, social and neuropsychiatric batteries, their medical history including diseases, using specific medication, family status. After that, vast number of different physiological quantitative traits is measured by using standardised protocols, and blood samples are taken to analyse biochemical indicators of different physiological domains.
    Types of tissue collected
: Blood, Plasma, Serum; Morning and 24h Urine; Feces, Scalp hair