The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)
    Web site for the cohort:
    http://www.medsci.uu.se/pivus/
    Publication describing the cohort:
  1. Lind L, Fors N, Hall J, Marttala K, Stenborg A. A Comparison of Three Different Methods to Evaluate Endothelium- Dependent Vasodilation in the Elderly. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. Arterioscler Thromb Vasc Biol. 2005; 25:2368-75.
    Description:
Community-based population randomly selected from the general population in the town of Uppsala, Sweden between April 2001 and June 2004: letter invitation in a randomised order (from the register of community living) within 2 months of their 70th birthday. Of the 2,025 subjects invited, 1,016 participated giving a participation rate of 50.1%. The primary aim of the PIVUS Study was to investigate the predictive power of different measurements of endothelial function and arterial compliance in subjects aged 70 living in the community of Uppsala. As secondary aims, the study also included measurements of cardiac function and structure by ultrasound and MRI, evaluation of atherosclerosis by ultrasound and MRI, 7 day food intake recordings, detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function, as well as a number of biochemical markers.
    Types of tissue collected
: – Serum stored at -80°C – Plasma stored at -80°C – Extracted DNA stored at -80°C