(The Hellenic Study of Interactions between SNPs and Eating in Atherosclerosis Susceptibility)
Publication describing the cohort:
- Theodoraki EV, Nikopensius T, Suhorutsenko J, Peppes V, Fili P, Kolovou G, Papamikos V, Richter D, Zakopoulos N, Krjutskov K, Metspalu A, Dedoussis GV. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. BMC Med Genet. 2010 Feb 18;11:28. doi: 10.1186/1471-2350-11-28.
: The THISEAS study participants were recruited from 3 hospitals found in the area of Athens. Cases were subjects with a first-ever MI before age of 70 years presenting with either ACS or stable CAD defined as >50% stenosis in at least one of the three main coronary vessels assessed by coronary angiography. ACS was defined as acute MI or unstable angina corresponding to class III of the Braunwald classification. ACS patients have also undergone coronary angiography examination that verified the presence of significant stenosis. Controls were subjects age matched without MI/CAD history with negative coronary angiography findings (<30% stenosis), or negative stress test, or subjects without symptoms of disease that were admitted at the same hospitals as cases and were free of any cardiovascular disease, cancer, or inflammatory diseases. Subjects with renal or hepatic disease were excluded from both study groups.
Types of tissue available
: Blood for
biochemical measurements as well as DNA and RNA isolation